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Research programme 03
Mutant p53 gain of function
We use p53 as a model to determine how cancer-associated mutations acquire new activities through altered structural and signaling interactions.
Cancer-associated p53 mutations differ in structure, residual activity and interaction partners. The laboratory investigates these differences rather than treating mutant p53 as a single entity.
By integrating biochemical, cellular and genomic evidence, this programme aims to identify variant-specific mechanisms and clinically meaningful biomarkers that can support precision oncology.
