Research
Our programmes connect DNA-damage signaling and TP53 mRNA architecture with mutant function, comparative biology and precision oncology.
We investigate structural interactions connecting ATM, the MRN complex, H2AX and p53 during the detection and repair of DNA double-strand breaks.
How are damage-sensing assemblies organized to transmit a precise p53 response?Explore this programme →
We study secondary structures in TP53 mRNA that control translation, co-translational events and the production of functionally distinct p53 proteins.
How does the structure of TP53 mRNA shape the protein response to stress?Explore this programme →
We use p53 as a model to determine how cancer-associated mutations acquire new activities through altered structural and signaling interactions.
Which molecular interfaces convert a TP53 variant into an oncogenic gain-of-function protein?Explore this programme →
We compare p53 systems across invertebrates, mammals and elephants to understand how development, stress adaptation and tumor suppression co-evolved.
What can diverse species teach us about the design principles of p53-mediated cancer resistance?Explore this programme →
