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Research programme 01
DNA-damage sensing and signaling
We investigate structural interactions connecting ATM, the MRN complex, H2AX and p53 during the detection and repair of DNA double-strand breaks.
The DNA-damage response depends on transient, highly organized protein interfaces. The laboratory studies how ATM kinase and damage-sensing components assemble, communicate and recruit downstream signaling pathways.
A central interest is how structural features of these interactions change cellular decisions between repair, arrest and apoptosis, and how cancer-associated alterations disrupt the network.
